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Facility & Equipment

Located 15 min from Toronto Pearson International Airport, the core capabilities of Covar’s formulation development and clinical supply manufacture facilities are:

Covar also provides full on-site analytical support, including method development, validation, and ICH stability testing.

  • High potency clinical supply manufacture

  • Wide variety of dosage form capabilities

  • Miniaturization equipment for API sparing

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Process Equipment

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Tablet manufacture

  • Single & bi-layer compression (Piccola Bilayer, instrumented)

  • Tablet & pellet coating (O’Hara)

  • Blending (≤ 2 cu ft)

  • Milling (comil/hammer mill)

  • Granulation (wet & dry)

 

Encapsulation

  • Liquid & powder filling

  • Capsule banding

  • Blister packing (thermoform, cold form)

Liquids, semi-solids & suspensions manufacture

 

Particle size reduction

  • Micronization (micron size)

  • Microfluidizer (nanoparticles)

 

Packaging & labelling

  • Blister packing (thermoform, cold form)

  • Vacuum sealing

  • Bottle & induction sealing

  • Clinical supply labelling (open label & double blinded)

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Analytical & Physical Testing

  • DSC

  • Dissolution & disintegration

  • FTIR & UV-Vis

  • HPLC (DAD, VWD, RID)

  • LC/MS (triple quadrupole)

  • Flash purification (Biotage)

  • Moisture analysis (LOD, KF)

  • Optical microscopy

  • Particle size (sieve analysis, laser diffraction)

  • PXRD

  • pH

  • Powder flow analysis & physical testing for tablets

  • TOC

  • Viscosity

  • ICH stability & photostability studies

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