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Specialty Dosage Forms

Tablets, Capsules & Pellets

Covar offers the full spectrum of oral solid dose technologies within a single integrated R&D and GMP manufacturing site. Our centralization and experience enable us to provide our clients with “bespoke” development plans, offering enhanced control, technology selection, and flexibility in your development program. Our deep experience in essentially all solid oral dosage forms from pre-development to commercialization provides assurance in the scalability of intellectual property, without sacrificing the flexibility and speed of a boutique organization.

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Due to the trend of oral solid dose products towards greater complexity (e.g. poorly soluble, combination products), Covar will often propose specialized technologies based on considerations of:

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  • Physicochemical properties of the drug substance

  • Pharmacokinetics and pharmacology

  • Materials science arising from specialized excipients and manufacture processes

  • Available funding and timetable for deliverables

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Capabilities:
Tablets
 

  • Conventional immediate release by direct compression, wet granulation, or dry granulation; with or without cosmetic coating

  • Modified release tablets by direct compression, wet granulation, or dry granulation with cosmetic or functional coating with specialty polymers (including diffusion/erosion-control)    

  • Bilayer tablets for fixed-dosed combination of two different actives or different release profiles of the same active, with or without functional coatings (e.g. enteric or targeted delivery)

  • Chewable tablets for pediatric formulations

  • Fast melt tablets (< 20 s) for fast oral disintegration

  • Sublingual tablets

  • Amorphous solid dispersion tablets

  • Reduced abuse potential tablets (e.g. narcotic preparations)

  • Matching placebos & manipulated tablets (e.g. comparator tablets) for clinical studies

Capsules
 

  • Conventional immediate release capsules

  • Liquid-filled hard gelatin/HPMC capsules (including lipid-based formulations)

  • Soft gelatin capsules (proof of concept)

  • Tablet in capsules prepared by over-encapsulation (e.g. for blinding)

Nanoparticle Formulations
 

  • Nanoparticle suspensions prepared by microfluidization or micronization

  • Nanoparticle in capsule or tablet formulations

  • Self-emulsifying tablets or capsules

Pellets/beads & mini tablets
 

  • Pellets in capsules with a variety of modified-release profiles (including with functional coatings)

  • Pellets compressed into tablets with a variety of modified-release profiles (including with functional coatings)

  • Pellets with multiple functional coatings for targeted delivery or multiple release profiles

  • Coating by direct electrostatic application with complete absence of water or solvents

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